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Team Project Name data analysis and image optimization algorithms
Establish reliable blood tau related biomarkers to will be carried out to provide the most efficient
clinical working model for accurate diagnosis and
diagnose and stage tauopathy assist in cost-benefit analysis to understand the
Research Project medical business model of how to improve the
This is a prospective 4-year research platform quality of life after early diagnosis.
to enhance the cost-effectiveness strategy for Key Words
diagnosing and staging Alzheimer disease (AD). Alzheimer Disease, Early Diagnosis, Digital
The clinical diagnosis of AD was based on amyloid Biological features, artificial intelligence assisted
and Tau PET results, with available plasma and diagnostic platform, plasma diagnostic biomarker,
genetic biomarkers. biosensor and biochips, Florzolotau images
Global Cooperation
Sub-project 1 will verify the mechanism of AD
and explored two indicators from EEG (Mismatch We would like to collaborate further research
negativity) and DTI-MRI (ALPS). projects through collaborations with the expert
team worldwide including, but not limited to, the
items below:
Sub-project 2 will verify the feasibility of a new a. Scientific investigation of neuroimaging, brain
plasma biomarker (mAb005) in staging AD. The mapping and clinical neurobehavioral data
performance will compare head-to-head with b. Big data collection and curation
available SIOMA biomarkers. Meanwhile, we also c. Artificial intelligence (AI) and deep learning
explored the feasibility of a biochip screening (DL) research methods discussions and
platform using a combination of biosensing collaborations
signals. d. Model training, testing, and validation
e. Algorithms and mathematical/statistical design
Sub-Project 3 will develop statistical and deep and implementation
learning algorithms especially for prognostic f. Plasma biomarkers and detection platforms
purposes using clinical, neuroimaging and genetic g. Research results and feedback.
data. Project Web Page
Cognitive and Aging Center at Chang Gung
Memorial Institute was established since 2009 and
continues to serve community-referred patients
with AD for accurate diagnosis and treatment. Big
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