Page 51 - brain-eBook

Team Project Name establish Taiwan's influence in precision health.

Innovative deep brain stimulation technology and Key Words
precision mental illness diagnosis and treatment platform Precision Psychiatry; Deep Brain Stimulation; Blood-
Research Project Based Biomarker; Schizophrenia; Bipolar Disorder;
The diagnosis of mental illness currently relies on Major Depression
symptomatic criteria as well as medical history and lacks Global Cooperation
objective instrument diagnosis. Also, current psychiatric
medicine, whether in diagnosis or treatment, is still highly Our team has established a close academic
dependent on experience-based rules and lacks precise collaboration with Professor Matcheri S. Keshavan from
treatment technology. Therefore, psychiatry urgently the Department of Psychiatry at Harvard Medical School,
needs to develop precise diagnoses and new treatment focusing on exploring brain biomarkers associated with
technologies. This project proposes the "Innovative mental illnesses. Additionally, we are privileged to be
Deep Brain Stimulation Technology and Precise Mental affiliated with the ENIGMA Consortium, collaborating
Illness Diagnosis and Treatment Platform." We will intensively with its scholars who specialize in the study
develop four innovative brain technologies, including of schizophrenia, bipolar disorder, and major depressive
(1) personalized brain lesion localization technology, (2) disorder. Monthly academic discussions are held with
novel blood biomarker diagnostic technology, (3) deep the consortium's expert teams, where we jointly delve
brain stimulation localization and electric field simulation into the latest research outcomes and findings. It is
technology, and (4) a novel brain deep stimulation noteworthy that the ENIGMA Consortium is globally
technology (Temporal Interference Brain Stimulation, recognized as the premier institution in neuroimaging
TIBS). We will focus on three major mental illnesses, and genomics research, bringing together research
including schizophrenia, bipolar disorder, and major teams from over 26 countries. The consortium's primary
depression, and use structural and functional MRI and mission is to harness neuroimaging and genetic data for
novel blood biomarkers to establish a rapid diagnosis an in-depth understanding of brain structure, function,
and identify abnormal brain regions that are related to and pathologies. Furthermore, in collaboration with
cognitive function decline and core psychiatric symptoms Professor Niels Kuster's team at the Eidgenössische
qualitatively and quantitatively. Through the localization Technische Hochschule Zürich (ETH Zürich), we are
of abnormal brain regions, we will use electric field developing cutting-edge Temporal Interference Brain
simulation technology to optimize the parameters of Stimulation (TIBS) with the aspiration of constructing
TIBS for human safety validation and conduct clinical comprehensive therapeutic devices. These devices
trials to treat the three major mental illnesses. We undergo clinical trials and human safety evaluations
expect to establish a precision psychiatry platform for for mental disorders. We anticipate collaborating with
the diagnosis and treatment of mental illnesses such as Professor Yang C. Fann from the National Institutes
schizophrenia, bipolar disorder, and major depression of Health in the United States to integrate a federated
and to optimize treatment parameters and methods for learning framework into our artificial intelligence model,
deep brain stimulation technology for treating these aiming to enhance its precision and stability.
diseases through human safety validation and clinical Project Web Page
trials. Ultimately, we will complete patent applications
in Taiwan and internationally, submit applications for
medical device approval, collaborate with the IT industry
for product commercialization, and work with clinical
institutions in Taiwan and internationally. This project
will stimulate the development of the neurotechnology
industry, improve the well-being of the people, and
50 51