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Team Project Name shorten the pre-clinical development timeline for

Utilizing a high-efficiency head-mounted miniscope drugs, and predict drug efficacy more accurately.
These techniques may also aid in the development
platform and artificial intelligence algorithms of treatments for other neurological diseases, such
to accelerate the development of cathepsin S as dementia and chronic pain. Ultimately, this new
inhibitors for treating Parkinson's disease-induced approach, which differs from traditional treatments,
motor dysfunction could offer an alternative strategy for treating
Research Project Parkinson's disease by protecting dopamine

This research project aims to develop a novel neurons.
treatment for Parkinson's disease, a condition Key Words
caused by the death of dopamine neurons in the
brain. Current treatments focus on increasing High-efficiency head-mounted microscope platform,
dopamine levels, but there is a lack of effective artificial intelligence algorithm, cathepsin S
strategies to prevent neuron death. The proposed inhibitor, Parkinson's disease treatment, movement
solution in this project is to utilize a high-efficiency dysfunction
head-mounted microscope platform combined Global Cooperation
with artificial intelligence algorithms to analyze
and quantify brain cell calcium signals, which In the international collaboration aspect of this
is believed to be a promising approach. Based project, a fully automated horizontal stereotaxic
on preliminary results, the hypothesis is that system will be developed, which is expected to
developing an in vivo active, highly selective benefit neuroscientists worldwide, particularly
Cathepsin S inhibitor could protect dopamine in popularizing the head-mounted microscope
neurons and, thus, prevent or treat Parkinson's platform technology. Moreover, the project
disease. The project has established a head- will develop two types of artificial intelligence
mounted microscope platform and successfully algorithms to assist in drug development and
recorded calcium imaging in the brains of awake predict the therapeutic efficacy of Parkinson's
mice, demonstrating that Cathepsin S levels disease drugs in animal models. The experience
increase with disease progression and that its gained during the development of these algorithms
inhibitors can effectively reduce motor dysfunction. can also be applied to drug development strategies
The specific goal of this project is to further develop for other neurodegenerative diseases. The
this high-efficiency brain cell calcium imaging project will also announce a candidate drug for
platform and establish AI algorithms to accelerate treating Parkinson's disease, a CTSS inhibitor that
the development of selective Cathepsin S inhibitors achieves therapeutic effects by protecting neural
for the treatment of Parkinson's disease. The cells, with the expectation of compensating for the
project involves collaboration with electronic deficiencies of currently available drugs.
engineers and medicinal chemists to manufacture Project Web Page
a high-precision stereotaxic device and conduct
animal efficacy tests. The innovation of this project
lies in the development of high-precision devices
and AI algorithms that are expected to popularize
head-mounted microscope platform technology,

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