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Team Project Name We will also develop novel gut-oriented PD
Gut-oriented therapeutics for Parkinson's biomarkers in response to the treatment of
disease through gutbrain axis Parabacteroides goldsteinii MTS01. Our
Research Project novel gut-oriented treatment strategies will
harmonize the gut microenvironment and
Parkinson’s disease (PD) is a common pave an avenue for a novel disease-modifying
neurodegenerative disorder without cure treatment of PD.
yet. The neuropathology of intraneuronal Key Words
α-synuclein aggregations (Lewy body) may
start from enteric nervous system subsequently Parkinson’s disease; gut-brain axis; gut
spreading to central dopaminergic neurons microbiota; National Taiwan University
through the gut-brain axis. We previously Hospital; National Taiwan University; LRRK2
have identified that transgenic PD mice were gene
more vulnerable to colitis, and subsequent Global Cooperation
developing PD through over-activating TLR4- This project aims to align with international
NF-kB and TNF-a related neuroinflammation research related to the gut-brain axis or
pathway. research and clinical trials focused on treating
Parkinson's disease with a gut-centric
approach.
Our group previously have identified a
bacterial strain, Parabacteroides goldsteinii Project Web Page
MTS01, which reduces colonic inflammation,
maintains intestinal barrier integrity and
ameliorates multiple chronic inflammation
related disorders. Based on these results, we
aim to evaluate the potential treatment efficacy
and molecular mechanism of Parabacteroides
goldsteinii MTS01 in a PD gut-brain axis
mouse model.
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