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Team Project Name Key Words

Developing a real-time closed-loop intelligent Mild cognitive impairment, MCI, dementia, closed
system for precision diagnosis and treatment of loop, electroencephalography, EEG, artifact
mild cognitive impairment subspace reconstruction, ASR, neurostimulation,
Research Project neur om odulat ion, bio-m ark er, ar t if ic ial
In an aging society where dementia is becoming intelligence, AI, machine learning, deep learning,
increasingly prevalent, it is crucial to focus on explainable AI, IoT, edge computing, healthcare,
the prevention and treatment of Mild Cognitive bioelectrochemistry, NYCU, BSTC, National Yang
Impairment (MCI), an early sign of dementia. Ming Chiao Tung University, Brain Science and
Non-invasive electrical stimulation is considered Technology Center
a method to modulate brain neural activity and Global Cooperation
enhance cognitive function. However, current 1.Clinical Data Collection: Besides patient data
clinical treatment often operates in generic provided by domestic medical institutions, we
settings without considering the individual patient's also welcome the exchange of physiological
condition. signal data from relevant overseas medical
institutions for MCI and Dementia patients to
Therefore, this project proposes an innovative enhance the content of our shared pathological
closed-loop neurostimulation system that combines database.
configurable electroencephalography (EEG) and 2.Clinical Trials: Currently, the development of
transcranial direct current stimulation (tDCS). The biomedical devices in Taiwan tends to be more
system monitors the brain dynamics features of conservative relative to foreign countries.
mild cognitive impairment (MCI) patients to access Therefore, besides collaborating with domestic
and evaluate the efficacy of closed-loop feedback medical units in clinical trials, we seek more
with tDCS for real-time adjusting the setting of opportunities for clinical trials by cooperating
neurostimulation to optimize therapeutic effects. with relevant overseas medical institutions.
3.Commercialization of the System: At present, it
This project includes: is generally difficult for the domestic biomedical
1.Diagnosis and examination for Mild Cognitive industry to secure funding. Collaborating with
Impairment (MCI) and the neurostimulation foreign partners to jointly commercialize the
system efficacy assessment for treatment system prototype and exploring foreign markets
(clinical execution/physiological data collection). is an option for cooperation.
2.Development of the system for analyzing Project Web Page
neurophysiological signal features of MCI and
constructing a closed-loop electrical stimulation
control model (physiological data analysis and
model establishment).

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