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Team Project Name Key Words
Research on Intelligent Adaptive Deep Brain National Yang Ming Chiao Tung University
Stimulation System for Precise Treatment of (NYCU) , Biomedical Electronics Translational,
Parkinson’s Disease Research Center (BETRC) , Parkinson’s
Research Project disease (PD) , Local field potential (LFP) , Beta
Closed-loop deep brain stimulation (DBS) is a oscillation (β oscillation) , Neuromodulation,
new technology in development. The local field Deep brain stimulation (DBS) , Closed loop,
potential (LFP) can be recorded with implanted Feedback control, Adaptive deep brain
stimulation, Biomarker, System-on-a-chip
DBS leads in the subthalamic nucleus (STN). In (SoC) , Analog front-end amplifier (AFEA) ,
Parkinson’s disease (PD) patients, there will be Analog-to-digital converter (ADC) , Digital bio-
abnormal low-frequency beta oscillation of LFP, signal processor, Stimulator, Wireless power
which can be considered as a biomarker of PD and data transceiver, Power management,
symptom. The Intelligent Deep Brain Stimulation Parkinsonian swine model
System uses the unique biomarker as the Global Cooperation
feedback control of closed-loop DBS.
This collaboration focuses on the development
of “SoC-based adaptive deep brain stimulation
The system is developed with system-on-a-chip platform”. This project combines the technology
(SoC) in combination with medical clinical needs advantages of Taiwan’s semiconductor industry
and semiconductor technology. It integrates with our integrated circuit (IC) design technique
LFP analog front-end amplifier, analog-to-digital for clinical applications in neurological diseases in
converter, digital signal processor, adjustable addition to Parkinson’s disease. With SoC (system
multi-channel electric stimulator, wireless on a chip) technology, some implantable medical
transmission, power management and other devices for precise diagnosis and treatment can
circuit functions. The system can enhance the be realized.
detection and stimulation function, reduce power Project Web Page
consumption, and improve treatment effect
and shelf life. It will reduce the side effects and
improve the efficacy of existing products to realize
the precise treatment of Parkinson’s disease.
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