Page 31 - brain-eBook

Team Project Name these methods will be validated using the identified

Brain aging: Muscle-to-brain axis modulates biological and neuroimaging biomarkers.
physio-cognitive decline In collaboration with international partners,
Research Project including the Japan National Center for Geriatric

Simultaneous declines in physical (walking and Gerontology and the US NIH/NIA, we aim to
maintain Taiwan's leading position in this field of
speed/grip strength) and cognitive function are research.
indicative of high risk for dementia among the
older people. In order to promote healthy aging, Key Words
our pioneering research aims to elucidate the Physio-cognitive decline syndrome, dementia,
mechanism linking skeletal muscle-to-brain cerebellum, skeletal muscle-to-brain axis,
regulation that contributes to the decline in both
physical and cognitive capabilities. The newly sarcopenia, cerebral small vessel disease,
discovered neurodegenerative pathway involves microRNA, brain MRI, brain network, multi-domain
the release of coding and non-coding RNA during intervention randomized controlled trial
muscle degeneration, which circulates to the brain,
accelerating aging in specific brain networks, Global Cooperation
ultimately leading to dual physical and cognitive 1. Utilize data from other countries' cohort
decline. studies to validate the clinical applications, the
mechanisms of brain structure and function, and
Three teams, focused on (i) biochemistry, (ii) treatment methods for physio-cognitive decline
neuroimaging, and (iii) community interventional syndrome.
clinical trials, will investigate this phenomenon 2. Increase the quantity of brain imaging dataset
using different approaches. The biochemistry team to improve the accuracy of our established
will utilize innovative models of muscle and neuron predictive models and facilitate international
aging to identify relevant factors and mechanisms. commercialization.
The large-scale brain imaging database will
employ machine learning techniques to identify Project Web Page
the corresponding brain regions/networks.
Furthermore, integrating the results from the
biochemistry and neuroimaging teams will facilitate
the development of diagnostic and treatment
methods to delay the simultaneous decline in
physical and cognitive functions. The efficacy of

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