Page 23 - brain-eBook

Team Project Name connectome, including cerebellar deep learning
computation and correlation coding among SCN
Advanced Optical Imaging Platform for Brain neurons in mouse.
Science
Research Project b.Multiscale structural mapping from synapse to
human brain
To unveil how a brain functions, it is necessary to These aims are tightly interconnected, and the
comprehend the underlying hardware and software, technical development are complementary to each
similar to understanding a computer. However, other, toward constructing a whole-brain functional
the main obstacle is lacking a suitable tool with connectome, as well as promote basic knowledge
enough spatiotemporal resolution to observe on neural diseases. We will not only seek
the physiological dynamics of an intact brain. opportunities to participate international projects,
Innovative technology has long been the driving enhancing global visibility of our island, but also
engine behind brain researches. In this project, we transfer our techniques to local companies,
have combined interdisciplinary (biology, medicine, improving industrial competitiveness of Taiwan.
physics, and engineering), inter-institute (AS, NTU, Key Words
NTHU, NYCU), and international (US, UK, Italy,
Japan, HK, NZ), to develop an advanced optical Laser scanning microscopy, high-speed imaging,
imaging platform, with the following aims: multiphoton excitation, photoacoustic imaging, light-
1.Optical techniques: sheet microscopy, stimulated Raman scattering,
interferometric scattering, microendoscopy,
a.Innovative contrast and speed for probing brain AI automatic image processing, contrast
functional responses, including field potentials, improvement, femtosecond laser development,
neurotransmitters, and ion transportation. brain connectomes, tremor, circadian rhythm, brain
b.Developing high-resolution, large volume bank
observation systems to examine whole-brain Global Cooperation
synaptic structure with 20-nm resolution
Joint development of optical techniques and
2.Information extraction techniques: analysis/simulation tools, as well as neuroscience
a.Constructing smart analysis toolbox to establish applications of state-of-the-art imaging modalities.
3D functional imaging process flow Project Web Page
b.Amalgamate functional imaging data with brain
circuit simulation, toward understanding the
underlying software

3.Translational research:
a.Unveiling function coding scheme in brain

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