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Team Project Name NeuLive-128 channel system integration, and
Developing an innovative precision temporal interference stimulation (TIS) simulation
and validation (patent pending). PEDOT coating
neuromodulation system for mechanistic reduced electrode impedance and improved signal-
investigation of cortico-basal ganglia circuit to-noise ratio. Our project promises a deeper CBG
dynamics and treating Parkinson’s disease circuit understanding and potential for precise
Research Project medicine, benefiting patients in need of neural
The project aims to understand DBS's therapeutic regulatory therapies.
mechanism in treating Parkinson's disease by Key Words
exploring cell-type-specific, pathway-specific, and Parkinson's disease, Large-scale neurophysiology,
cortical region/layer-specific neuromodulation cortico-basal ganglia neural circuit, Deep-
within the CBG circuit. Additionally, a precision brain stimulation, Parkinson’s disease, Cortical
bidirectional neuromodulator, NeuLive-T, is being stimulation, Precision neuromodulation, Precision
developed for high-resolution neuromodulation medicine, Microwire bundle, Basal ganglia,
and insights into CBG circuit mechanisms. In Subthalamic nucleus (STN), Optogenetics, Neural
the Neuroscience Subprojects, five experimental engineering, Wireless neural recording, Temporal
platforms have been established: (1) STN- interference stimulation, Dopamine sensing
specific gene knockout, (2) electrophysiology
and optogenetics for STN slices, (3) motor cortex Global Cooperation
electrical stimulation, (4) STN optogenetics
and TRAP labeling, and (5) two-photon calcium 1. Cortico-basal ganglia neural circuit and their role
imaging. Results indicate that the motor cortex in movement disorders in rodant model.
can regulate STN neuron discharge, impaired in 2. Neurophysiology from single cell patch-clamp
Parkinson's but restorable with precise STN DC recording to large-scale in vivo extracellular
stimulation or dopamine. Cortex-STN pathway recording, i.e. large-scale cortical and subcortical
dysregulation contributes to tremors. Excitatory extracellular recordings.
synapses in STN neurons are Foxp2-regulated. 3. In vivo two-photon calcium imaging for cortex
"STN-specific Foxp2 gene knockout mice" exhibit and deep-brain areas through GRIN lens, i.e.
Parkinson's symptoms. Future research will striatum and STN.
explore Foxp2-expressing neural types. Specific 4. Neural dynamical system signal processing and
DC motor cortex stimulation improves Parkinsonian data analysis.
symptoms and increases neural discharge. 5. Neural decoding and brain-computer interface.
STN stimulation shows layer-specific cortical Project Web Page
activity heterogeneity. Subprojects demonstrate
therapeutic potential in regulating motor cortex
neurons and tuning STN membrane potential. In
Neural Engineering aspects, achievements include
a microelectrode array manufacturing pipeline,
scalable array technology (patent pending),
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